Postdoktorand in der Arbeitsgrupe Prof. Dr. Eckart Rühl (TP B02)
Physikalische und Theoretische Chemie
Institut für Chemie und Biochemie
Fachbereich Biologie, Chemie, Pharmazie
Freie Universität Berlin

Kontakt

Teilprojekt B02:
Spatially and temporally resolved studies on the transport of nanocarriers and drug release in cells and skin

SFB 1112-Publikationen:

Schulz R, Yamamoto K, Klossek A, Flesch R, Hönzke S, Rancan F, Vogt A, Blume-Peytavi U, Hedtrich S, Schäfer-Korting M, Rühl E, Netz RR 2017. Data-based modeling of drug penetration profiles explains human skin barrier function by the interplay of diffusivity and free energy profiles. Proc Nat Acad Sci DOI 10.1073/pnas.1620636114 (epublication ahead of print)

Giulbudagian M, Rancan F, Klossek A, Yamamoto K, Jurisch J, Colombo Neto V, Schrade P, Bachmann S, Rühl E, Blume-Peytavi U, Vogt A, Calderón M 2016. Correlation between the chemical composition of thermoresponsive nanogels and their interaction with the skin barrier. J Contr Release 243:323-332 DOI 10.1016/j.jconrel.2016.10.022

Klossek A, Thierbach S, Rancan F, Vogt A, Blume-Peytavi U, Rühl E 2016. Studies for improved understanding of lipid distributions in human skin by combining stimulated and spontaneous Raman microscopy. Eur J Pharm Biopharm, in press, DOI: 10.1016/j.ejpb.2016.11.001

Yamamoto K, Klossek A, Flesch R, Rancan F, Weigand M, Bykova I,Bechtel M, Ahlberg S, Vogt A, Blume-Peytavi U, Schrade P, Bachmann S, Hedtrich S, Schäfer-Korting M, Rühl E 2016. Influence of the skin barrier on the penetration of topically-applied dexamethasone probed by soft X-ray spectromicroscopy. Accepted for publication in: Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.12.005

Yamamoto K, Klossek A, Flesch R, Ohigashi T, Fleige E, Rancan F, Ahlberg S, Vogt A, Blume-Peytavi U, Schrade P,  Bachmann S, Haag R, Hedtrich S, Schäfer-Korting M, Kosugi N, Rühl E 2016. Core-multishell nanocarriers: Transport and release of dexamethasone probed by soft X-ray spectromicroscopy. J Control Release 242:64-70 DOI 10.1016/j.jconrel.2016.08.028

Yamamoto K, Flesch R, Ohigashi T, Hedtrich S, Klossek A, Patoka P, Ulrich G, Ahlberg S, Rancan F,  Vogt A, Blume-Peytavi U, Schrade P, Bachmann S, Schäfer-Korting M, Kosugi N, Rühl E 2015. Selective probing of the penetration of dexamethasone into human skin by soft-X-ray spectromicroscopy. Anal Chem 87:6173-6179 DOI 10.1021/acs.analchem.5b00800