Stefan Hönzke, Apotheker

Doktorand in der Arbeitsgruppe Prof. Dr. Sarah Hedtrich (TP C02)
Pharmakologie und Toxikologie
Institut für Pharmazie
Fachbereich Biologie, Chemie, Pharmazie
Freie Universität Berlin

Kontakt:
Tel. +49 30 838 53944
Email: shoenzke (at) zedat.fu-berlin.de

Dissertationsthema:

Die Entwicklung von in vitro Modellen entzündlicher Hauterkrankungen als Testplattform zur systematischen Untersuchung von nanopartikulären Trägersystemen hinsichtlich Effektivität und Toxizität



Erstbetreuerin:                        Prof. Dr. Monika-Schäfer-Korting

Zweitbetreuerin:                       Prof. Dr. Sarah Hedtrich

Drittbetreuer/Mentor:                Jun.-Prof. Dr. Marcelo Calderón


Publikationen:

Giulbudagian M, Hönzke S, Bergueiro J, Isik D, Schumacher F, Saeidpour S, Lohan SB, Meinke MC, Teutloff C, Schäfer-Korting M, Yealland G, Kleuser B, Hedtrich S, Calderón M 2017. Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels. Accepted for publication in: Nanoscale DOI 10.1039/C7NR04480A

Giulbudagian M, Yealland G, Hönzke S, Edlich A, Geisendörfer B, Kleuser B, Hedtrich S, Calderón M 2018. Breaking the barrier - potent anti-inflammatory activity following efficient topical delivery of etanercept using thermoresponsive nanogels. Theranostics 8:450-463 DOI 10.7150/thno.21668

Pischon H, Radbruch M, Ostrowski A, Schumacher F, Hönzke S, Kleuser B, Hedtrich S, Fluhr JW, Gruber AD, Mundhenk L 2017. How effective is tacrolimus in the imiquimod-induced mouse model of psoriasis? J Invest Dermatol. Epub ahead of print. DOI 10.1016/j.jid.2017.09.019

Balzus B, Sahle FF, Hönzke S, Gerecke C, Schumacher F, Hedtrich S, Kleuser B, Bodmeier R 2017. Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium. Accepted for publication in: Eur J Pharm Biopharm DOI 10.1016/j.ejpb.2017.02.001

Müller F, Hönzke S, Luthardt W-O, Wong EL, Unbehauen M, Bauer J, Haag R, Hedtrich S, Rühl E, Rademann J. Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery. Accepted for publication in Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.12.013

Pischon H, Radbruch M, Ostrowski A, Volz P, Gerecke C, Unbehauen M, Hönzke S, Hedtrich S, Fluhr JW, Haag R, Kleuser B, Alexiev U, Gruber AD, Mundhenk L 2016. Stratum corneum targeting by dendritic core-multishell-nanocarriers in a mouse model of psoriasis. Nanomedicine: NBM 13:317-327 DOI 10.1016/j.nano.2016.09.004

Schulz R, Yamamoto K, Klossek A, Flesch R, Hönzke S, Rancan F, Vogt A, Blume-Peytavi U, Hedtrich S, Schäfer-Korting M, Rühl E, Netz RR 2017. Data-based modeling of drug penetration profiles explains human skin barrier function by the interplay of diffusivity and free energy profiles, Accepted for publication: Proc Nat Acad Sci

Döge N, Hönzke S, Schumacher F, Balzus B, Colombo M, Hadam S, Rancan F, Blume-Peytavi U, Schäfer-Korting M, Schindler A, Rühl E, Stahl Skov P, Church M, Hedtrich S, Kleuser B, Bodmeier R, Vogt A 2016. Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivohuman skin -assessment by intradermal microdialysis and extraction from the different skin layers. J Control Release 242:25-34 DOI 10.1016/j.jconrel.2016.07.009

Du F, Hönzke S, Neumann F, Keilitz J, Chen W, Ma N, Hedtrich S, Haag R 2016. Development of biodegradable hyperbranched core-multishell nanocarriers for efficient topical drug delivery. J Control Release, 242:42-49 DOI 10.1016/j.jconrel.2016.06.048

Hönzke S, Gerecke C, Elpelt A, Zhang N, Unbehauen M, Kral V, Fleige E, Paulus F, Haag R, Schäfer-Korting M, Kleuser B, Hedtrich S 2016. Tailored dendritic core-multishell nanocarriers for efficient dermal drug delivery: A systematic top-down approach from synthesis to preclinical testing. J Control Release 242:50-63. DOI 10.1016/j.jconrel.2016.06.030

Stefani S, Hönzke S, Cuellar Camach JL, Neumann F, Prasad AK, Hedtrich S, Haag R, Servin P 2016. Hyperbranched glycerol-based core-amphiphilic branched shell nanotransproters for dermal drug delivery. Polymer 96:156-166 DOI 10.1016/j.polymer.2016.04.074

Adeli M, Namazi H, Du F, Hönzke S, Hedtrich S, Keilitz J, Haag R 2015. Synthesis of multiarm star copolymers based on polyglycerol cores with polylactide arms and their application as nanocarriers. RSC Adv 5:14958 DOI 10.1039/c4ra14619k (epub)

Hönzke S, Wallmeyer L, Ostrowski A, Radbruch M, Mundhenk L, Schäfer-Korting M, Hedtrich S 2015. Influence of Th2 cytokines on the cornified envelope, tight junction proteins and ß-defensins in filaggrin-deficient skin models. J Invest Dermatol 136:631-639DOI 10.1016/j.jid.2015.11.007 (ROSA-Award, Forschungspreis Atopische Dermatitis 2016, La Roche-Posay)