Dr. Alexander Boreham

ehemaliger assoziierter Doktorand und Postdoktorand in der Arbeitsgruppe von Prof. Dr. Ulrike Alexiev, Teilprojekt B03


Dissertationsthema:

From molecules to tissue. Fluorescence spectroscopy and microscopy of nanoparticles and biomolecules involved in inflammation and pain


Dissertationsprojekt abgeschlossen im Juli 2014



SFB 1112- Publikationen:

Alexiev U, Volz P, Boreham A, Brodwolf R 2017. Time-resolved fluorescence microscopy (FLIM) as an analytical tool in skin nanomedicine. Accepted for publication in: Eur J Pharm Biopharm DOI 10.1016/j.ejpb.2017.02.005 (Review)

Löwenau LJ, Zoschke C, Brodwolf R, Volz P, Hausmann C, Wattanapitayakul S, Boreham A, Alexiev U, Schäfer-Korting M 2017. Increased permeability of reconstructed human epidermis from UVB-irradiated keratinocytes. Accepted for publication in  Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.12.017

Zhang N, Said A, Wischke C, Kral V, Brodwolf R, Volz P, Boreham A, Gerecke C, Li W, Neffe AT, Kleuser B, Alexiev U, Lendlein A, Schäfer-Korting M 2017. Poly[acrylonitrile-co-(N-vinyl pyrrolidone)] nanoparticles - composition-dependent skin penetration enhancement of a dye probe and biocompatibility. Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.10.019 (Epub ahead of print)

Boreham AVolz P, Peters D, Keck CM, Alexiev U 2017. Determination of nanostructures and drug distribution in lipid nanoparticles by single molecule microscopyEur J Pharm Biopharm 110:31-38 DOI 10.1016/j.ejpb.2016.10.020

Boreham A, Pikkemaat J, Volz P, Brodwolf R, Kuehne C, Licha K, Haag R, Dernedde J, Alexiev U 2016. Detecting and quantifying biomolecular interactions of a dendritic polyglycerol sulfate nanoparticle using fluorescence lifetime measurements. Molecules 21:22 DOI: 10.3390/molecules21010022 (epub, 13 pages)

Ostrowski A, Nordmeyer D, Boreham A, Holzhausen C, Mundhenk L, Graf C, Meinke M, Vogt A, Haddam S, Lademann J, Rühl R, Alexiev U, Gruber AD 2015. Overview on the Localization of Nanoparticles in Tissue and Cellular Context by Different Imaging Techniques. (Review) Beilstein J Nanotech 6:263-280 DOI10.3762/bjnano.6.25 (epub)

Volz P, Boreham A, Wolf A, Kim T-Y, Balke J, Frombach J, Hadam S, Afraz Z, Rancan F, Blume-Peytavi U, Vogt A, Alexiev U 2015. Application of single molecule fluorescence microscopy to characterize the penetration of a large amphiphilic molecule in the stratum corneum of human skin. Int J Mol Sci 16: 6960-6977 DOI 10.3390/ijms16046960

Witting M, Boreham A, Brodwolf R, Vávrová K, Alexiev U, Friess W, Hedtrich S 2015. Interactions of hyaluronic acid with the skin and implications for the dermal delivery of biomacromolecules. Mol Pharm 12:1391-1401 DOI 10.1021/mp500676e

Alnasif N, Zoschke C, Fleige E, Brodwolf R, Boreham A, Rühl E, Eckl KM, Merk HF, Hennies HC, Alexiev U, Haag R, Küchler S, Schäfer-Korting M 2014. Penetration of normal, damaged and diseased skin - An in vitro study on dendritic core-multishell nanotransporters. J Control Release 185:45-50 DOI 10.1016/j.jconrel.2014.04.006

Boreham A, Pfaff M, Fleige E, Haag R, Alexiev U 2014. Nanodynamics of dendritic core-multishell nanocarriers. Langmuir 30:1686-1695 DOI 10.1021/la4043155

Boreham A, Brodwolf R, Pfaff M, Kim T-Y, Schlieter T, Mundhenk L, Gruber AD, Gröger D, Licha K, Haag R, Alexiev U 2014. Temperature and environment dependent dynamic properties of a dendritic polyglycerol sulfate. Polym Adv Technol 25:1329-1336 DOI 10.1002/pat.3355

Ostrowski A, Nordmeyer D, Boreham A, Brodwolf R, Mundhenk L, Fluhr JW, Lademann J, Graf C, Rühl E, Alexiev U, Gruber AD 2014. Skin barrier disruptions in tape stripped and allergic dermatitis models have no effect on dermal penetration and systemic distribution of AHAPS-functionalized silica nanoparticles. Nanomedicine 10:1571-1581. DOI 10.1016/j.nano.2014.04.004