Giulbudagian G, Yealland G, Hönzke S, Edlich A, Geisendörfer B, Kleuser B, Hedtrich S, Calderón M 2018. Breaking the barrier - potent anti-inflammatory activity following efficient topical delivery of etanercept using thermoresponsive nanogels. Theranostics 8:450-463 DOI 10.7150/thno.21668
Frontcover Theranostics 2018:8(2)
Combination of Surface Charge and Size Controls the Cellular Uptake of Functionalized Graphene Sheets
Zhaoxu Tu, Katharina Achazi, Andrea Schulz, Rolf Mülhaupt, Steffen Thierbach, Eckart Rühl, Mohsen Adeli, and Rainer Haag, Adv. Funct. Mater. 2017, 27, 17018377
European Journal of Pharmaceutics and Biopharmaceutics, 2017, Volume 116, Pages 1-164
Data-based modeling of drug penetration relates human skin barrier function to the interplay of diffusivity and free-energy profiles
Robert Schulz, Kenji Yamamoto, André Klossek, Roman Flesch, Stefan Hönzke, Fiorenza Rancan, Annika Vogt, Ulrike Blume-Peytavi, Sarah Hedtrich, Monika Schäfer-Korting, Eckart Rühl, and Roland R. Netz, Proc. Natl. Acad. Sci. USA 2017, 114(14), 3631-36366
Roboter im Blut ("Robots in the blood"), ARTE-TV report by Mathilde Schnee
Since the first use of the term "nanotechnology" in 1974, research has advanced significantly. At the Institute of Chemistry and Biochemistry of Freie Universität Berlin, so-called nanocarriers were developed: tiny transporters for targeted drug delivery. As a spin-off from the university team, a start-up company is testing the new technology for skin drug delivery in cats and has been awarded the Berlin-Brandenburg Innovation Prize.
Taken from: info.arte.tv, ARTE (German only)
Well-wrapped on target: Freie Universität Berlin has been issued a European patent for a gel capsule designed as a nanocarrier for drug delivery in the human body. The nanogel releases its susceptible drug cargo - enzymes or proteins - directly on the desired site of action, e.g. in the environment of inflamed or tumor tissue, because altered acidic tissue pH associated with these pathologies will lead to dissolution of the nanogel 'wrap'.
The nanogel is composed of polyglycerin and can release its cargo on the target site without additional action of tensides, ultrasound or heat that are commonly used for on-site drug release from nanocarriers. Thus, the therapeutic properties of labile drug biomolecules are maintained using the patented nanogel. The nanogel capsule was invented by Rainer Haag, Professor at Institute of Chemistry and Biochemistry of Freie Universität Berlin, and Dirk Steinhilber, doctoral student with R. Haag, as well as by scientists from LMU München.
News-item Profund Innovation, Freie Universität Berlin (German only)
Core-multishell nanocarriers: Transport and release of dexamethasone probed by soft X-ray spectromicroscopy
K. Yamamoto, A. Klossek, R. Flesch, T. Ohigashi, E. Fleige, F. Rancan, J. Frombach, A. Vogt, U. Blume-Peytavi, P. Schrade, S. Bachmann, R. Haag, S. Hedtrich, M. Schäfer-Korting, N. Kosugi, E. Rühl, J. Control. Release 2016, 242, 64-70
Journal of Controlled Release, 2016, Volume 242, Pages e1-e6, 1-148
The groups of Prof. Dr. Marcelo Calderón and Prof. Dr. Sarah Hedtrich present latest SFB 1112-research news in the "Scientifically Speaking" category of the current CRS Newsletter (member only publication of the Controlled Release Society):
Dendritic polyglycerol-based nanogels for dermal drug delivery. Molina M, Witting M, Calderón M, Hedtrich S 2016. CRS Newsletter 33(4):10-12
The group of Prof. Calderón has developed new thermo-nanogels for the encapsulation of drugs, with a gradual drug release at the site of action. Potential fields of application for the nanogels are modern tumor therapies and topical therapy of inflammatory skin diseases such as psoriasis and atopic dermatitis.
Newsmeldung Profund Innovation, Freie Universität Berlin (German only)
Freie Universität Berlin, Stabsstelle Presse und Kommunikation, Wissenschaft aktuell, 2016, Themen im September
Award-winning SFB 1112-publication:
Influence of Th2 cytokines on the cornified envelope, tight junction proteins and ß-defensins in filaggrin-deficient skin models. Hönzke S, Wallmeyer L, Ostrowski A, Radbruch M, Mundhenk L, Schäfer-Korting M, Hedtrich S 2015. J Invest Dermatol 136:631-639 DOI 10.1016/j.jid.2015.11.007 (19.11.2015)
Nanocarriers for drug delivery into and through the skin - do existing technologies match clinical challenges?
A. Vogt, C. Wischke, A. T. Neffe, N. Ma, U. Alexiev, and A. Lendlein, J. Control. Release 2016, in press, DOI 10.1016/j.jconrel.2016.07.027 (Review)
Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivohuman skin -assessment by intradermal microdialysis and extraction from the different skin layers.
N. Döge, S. Hönzke, F. Schumacher, B. Balzus, M. Colombo, S. Hadam, F. Rancan, U. Blume-Peytavi, M. Schäfer-Korting, A. Schindler, E. Rühl, P. Stahl Skov, M. Church, S. Hedtrich, B. Kleuser, R. Bodmeier, and A. Vogt, J Control Release 2016, in press, DOI 10.1016/j.jconrel.2016.07.009 (Epub ahead of print)
The recent SFB-Publication Yamamoto et al. on "Selective Probing of the Penetration of Dexamethasone into Human Skin by Soft-X-Ray Spectromicroscopy", Anal Chem 2015, 87, 6173–6179, was featured as scientific highlight in the Annual Report 2014 of UVSOR Facility, National Institutes of Natural Sciences, Institute for Molecular Science, Okazaki/Japan.
Selective Probing of the Penetration of Dexamethasone into Human Skin by Soft X-ray Spectromicroscopy
K. Yamamoto, R. Flesch, T. Ohigashi, S. Hedtrich, A. Klossek, P. Patoka, G. Ulrich, S. Ahlberg, F. Rancan, A. Vogt, U. Blume-Peytavi, P. Schrade, S. Bachmann, M. Schäfer-Korting, N. Kosugi, and E. Rühl, Anal. Chem. 2015, 87(12), 6173-6179
Prof. Dr. Sarah Hedtrich (Project C02) was awarded with the "Astellas Forschungspreis 2015" (Astellas Research Award 2015) for her work on atopic Dermatitis.
Fabrication of Thermoresponsive Nanogels by Thermo-Nanoprecipitation and in situ Encapsulation of Bioactives
M. Giulbudagian, M. Asadian-Birjand, D. Steinhilber, K. Achazi, M. A. Molina, M. Calderón, Polymer Chemistry 2014, 5, 6909-6913
Report on poster-prizes ("Hans Christian Korting-Nachwuchspreis für Dermopharmazie") awarded to members of SFB 1112 on the 18th Annual Conference of the German Dermopharmceutical Society/Gesellschaft für Dermopharmazie; DermoTopics, Issue 1/2014
Report on on the 18th Annual Conference of the German Dermopharmceutical Society/Gesellschaft für Dermopharmazie and poster-prizes ("Hans Christian Korting-Nachwuchspreis für Dermopharmazie") awarded to members of SFB 1112; DAZ 2014, Nr. 16, S. 87 17.04.2014
A Microgel Construction Kit for Bioorthogonal Encapsulation and pH-Controlled Release of Living Cells
D. Steinhilber, T. Rossow, S. Wedepohl, F. Paulus, S. Seiffert, R. Haag, Angew. Chem. Int. Ed. 2013, 52(51), 13538-13543