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Special Lecture "Drug Targeting and Molecular Imaging" / 21 240 V (Licha)


Dr. Kai Licha, Institut für Chemie und Biochemie, FU Berlin + Fa. mivenion

Work load: 2 SWS, 3 CP

Time: Tuesdays, 8:30 - 10:00 hrs / 8:30  - 10:00 am
Starting: 15. April 2014

Location: Institut für Chemie und Biochemie - Organische Chemie, FU Berlin, Takustraße 3, Room 34.16-17


1. Principles of therapeutic drugs (classes, modes of action, chemical examples) and treatment modalities (chemotherapy, anti-angiogenesis, physical methods photodynamic therapy, radiotherapy)

2. Background on pharmacology (pharmacokinetics, ADMET) and principles of "drug delivery" and "drug targeting," passive vs active targeting. Molecular imaging: basic principles of diagnostic modalties

3. Signalling molecules: mode of action, chemistry, examples: applications as tool to monitor and evaluate drug targeting and therapeutic efficacy ("theranostics")
4. Synthetic chemistry for drug conjugation (reactive groups, cleavable groups)
5. Drug targeting and molecular imaging based on biologic targeting molecules: antibodies, proteins, peptides, glycans, oligonucleotides
6. Drug targeting and imaging based on formulations, polymers, nanoparticles, dendrimers: principles, chemistry, examples
7. Basics of drug development: clinical phases, IND, drug master file

For more information please see here