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Publikationen des SFB 1112

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(in chronologischer Reihenfolge)

Döge N, Hadam S, Volz P, Wolf A, Schönborn K-H, Blume-Peytavi U, Alexiev U, Vogt A 2018. Identification of polystyrene nanoparticle penetration across intact skin barrier as rare event at sites of focal particle aggregations. Accepted for publication in: J Biophotonics 201700169(10 pages) DOI 10.1002/jbio.201700169

Giulbudagian M, Hönzke S, Bergueiro J, Isik D, Schumacher F, Saeidpour S, Lohan SB, Meinke MC, Teutloff C, Schäfer-Korting M, Yealland G, Kleuser B, Hedtrich S, Calderón M 2018. Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels. Nanoscale 10(1):469-479 DOI 10.1039/C7NR04480A

Giulbudagian G, Yealland G, Hönzke S, Edlich A, Geisendörfer B, Kleuser B, Hedtrich S, Calderón M 2018. Breaking the barrier - potent anti-inflammatory activity following efficient topical delivery of etanercept using thermoresponsive nanogels. Theranostics 8:450-463 DOI 10.7150/thno.21668 (Frontcover-Highlight)

Pischon H, Radbruch M, Ostrowski A, Schumacher F, Hönzke S, Kleuser B, Hedtrich S, Fluhr JW, Gruber AD, Mundhenk L 2018. How effective is tacrolimus in the imiquimod-induced mouse model of psoriasis? J Invest Dermatol 138:455-458 DOI 10.1016/j.jid.2017.09.019

Jager J, Obst K, Lohan SB, Voktorov J, Staufenbiel S, Renz H, Unbehauen M, Haag R, Hedtrich S, Teutloff C, Meinke MC, Danker K, Dommisch H 2018. Characterization of hyperbranched core-multishell nanocarriers as an innovative drug delivery system for the application at the oral mucosa. J Periodontal Res. 53(1):57-65 DOI 10.1111/jre.12487

Lademann J, Knorr F, Patzelt A, Meinke MC, Richter H, Krutmann J, Rühl E, DoucetO 2018.  Laser scanning microscopic investigations of the decontamination of soot particles from the skin. Skin Pharmacol. Physiol.31:87-94 DOI: 10.1159/000485900


(in chronologischer Reihenfolge)

Kanduc M
, Schlaich A, de Vries AH, Jouhet J, Maréchal E, Demé B, Netz RR, Schneck E 2017. Tight cohesion between glycolipid membranes results from balanced water–headgroup interactions. Nature Communications 8:14899(9 pages) DOI 10.1038/ncomms14899

Wang W, Nalou T, Ma N, Deng Z, Xu X, Mansfeld U, Wischke C, Gossen M, Neffe AT, Lendlein A 2017. Polydepsipeptide block-stabilized polyplexes for efficient transfection of primary human cells. Biomacromolecules 18:3819-3833 DOI 10.1021/acs.biomac.7b01034

Dimde M, Neumann F, Reisbeck F, Ehrmann S, Cuellar-Camacho JL, Steinhilber D, Ma N, Haag R 2017. Defined pH-sensitive nanogels as gene delivery platform for siRNA mediated in vitro gene silencing. Biomater Sci 5:2328-2336 DOI 10.1039/c7bm00729a

Volz P, Schilrreff P, Brodwolf R, Wolff C, Stellmacher J, Balke J, Morilla MJ, Zoschke C, Schäfer-Korting M, Alexiev U 2017. Pitfalls in using fluorescence tagging of nanomaterials: tecto-dendrimers in skin tissue as investigated by Cluster-FLIM. Ann NY Acad Sci 1405:202-214 DOI 10.1111/nyas.13473

Mohammadifar E, Zabihi F, Tu Z, Hedtrich S, Nemati A, Adeli M, Haag R 2017. One-pot and gram-scale synthesis of biodegradable polyglycerol at ambient conditions; nanocarriers for intradermal drug delivery. Polym Chem 8(47):7375-7383 DOI 10.1039/c7py01470h

Wang W, Deng Z, Xu X, Li Z, Jung F, Ma N, Lendlein A 2017. Functional nanoparticles and their Interactions with mesenchymal stem cells. Curr Pharm Des 23:1-19 DOI 10.2174/1381612823666170622110654 (Review)

Wang W, Li W, Wang J, Hu Q, Balk M, Bieback K, Stamm C, Jung F, Tang G, Lendlein A, Ma N 2017. Folate receptor mediated genetic modification of human mesenchymal stem cells via folic acid-polyethylenimine-grafted poly(N-3-hydroxypropyl)aspartamide. Clin Hemorheol Microcirc 67(3-4):279-295 DOI 10.3233/CH-179209

Tu Z, Achazi K, Schulz A, Mülhaupt R, Thierbach S, Rühl E, Adeli M, Haag R. 2017. Combination of surface charge and size controls the cellular uptake of functionalized graphene sheets. Adv Funct Mater 27(33):1701837(11 pages) DOI 10.1002/adfm.201701837

Lohan SB, Ahlberg S, Mensch A, Höppe D, Giulbudagian M, Calderón M, Grether-Beck S, Krutmann J, Lademann J, Meinke MC 2017. EPR technology as sensitive method for oxidative stress detection in primary and secondary keratinocytes induced by two selected nanoparticles. Cell Biochem Biophys 75(3-4):359-367 DOI 10.1007/s12013-017-0823-4

Unbehauen ML, Fleige E, Paulus F, Schemmer B, Mecking S, Moré SD, Haag R 2017. Biodegradable core–multishell nanocarriers: Influence of inner shell structure on the encapsulation behavior of dexamethasone and tacrolimus. Polymers 9(8):316(17 pages) DOI 10.3390/polym9080316

Herrmann P, Kästner B, Hoehl A, Kashcheyevs V, Patoka P, Ulrich G, Feikes J, Ries M, Tydecks T, Beckhoff B, Rühl E, Ulm G 2017. Enhancing the sensitivity of nano-FTIR spectroscopy. Opt Express 25:16574-16588  DOI 10.1364/OE.25.016574

Wallmeyer L, Dietert K, Sochorova M, Gruber AD, Kleuser B, Vavrova K, Hedtrich S 2017. TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents. Sci Rep 7:774(12 pages) DOI 10.1038/s41598-017-00670-2

Obst K, Yealland G, Miceli E, Dimde M, Balzus B, Weise C, Eravci M, Bodmeier R, Haag R, Calderón M, Charbaji N, Hedtrich S 2017. Protein corona formation on polymeric nanoparticles possessing porous, solid and PEG-based surfaces of varied surface charge and hydrophobicity: impact on cellular uptake, toxicity, immunogenicity and drug release properties. Biomacromolecules 18:1762-1771 DOI 10.1021/acs.biomac.7b00158

Wieczorek S, Remmler D, Masini T, Kochovski Z, Hirsch AKH, Börner HG 2017. Fine-tuning nanocarriers specifically toward cargo: A competitive study on solubilizing related photosensitizers for photodynamic therapy. Bioconjug Chem 28:760-767 DOI 10.1021/acs.bioconjchem.6b00549

Ceylan Tuncaboylu D, Wischke C, Störmann F, Lendlein A 2017. Microgels from microfluidic templating and photoinduced crosslinking of cinnamylidene acetic acid modified precursors. React Funct Polym 112:68-73 DOI 10.1016/j.reactfunctpolym.2016.12.015

Dimde M, Sahle FF, Wycisk V, Steinhilber D, Cuellar L, Licha K, Lademann J, Haag R 2017. Synthesis and validation of functional nanogels as pH-sensors in the hair follicle. Macromol Bioscience 17(10):1600505(8 pages) DOI 10.1002/mabi.201600505

Naolou T, Rühl E, Lendlein E 2017. Nanocarriers: Architecture, transport, and topical application of drugs for therapeutic use. Eur J Pharm Biopharm 116:1-3 DOI 10.106/j.ejpb.2017.03.004 (Editorial)

Gerecke C, Edlich A, Giulbudagian M, Schumacher F, Zhang N, Said A, Yealland G, Lohan SB, Neumann F, Meinke MC, Ma N, Calderón M, Hedtrich S, Schäfer-Korting M, Kleuser B 2017. Biocompatibility and characterization of polyglycerol-based thermoresponsivenanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes. Nanotoxicology 11(2): 267-277 DOI 10.1080/17435390.2017.1292371

Schulz R, Yamamoto K, Klossek A, Flesch R, Hönzke S, Rancan F, Vogt A, Blume-Peytavi U, Hedtrich S, Schäfer-Korting M, Rühl E, Netz RR 2017. Data-based modeling of drug penetration profiles explains human skin barrier     function by the interplay of diffusivity and free energy profiles. Proc Nat Acad Sci 114:3631-3636  DOI 10.1073/pnas.1620636114

Lohan SB, Saeidpour S, Solik A, Schanzer S, Richter H, Dong P, Darvin ME, Bodmeier R, Patzelt A, Zoubari G, Unbehauen M, Haag R, Lademann J, Teutloff C, Bittl R, Meinke MC 2017. Investigation of the cutaneous penetration behavior of dexamethasone loaded to nano-sized lipid particles by EPR spectroscopy, and confocal Raman and Laser scanning microscopy. Eur J Pharm Biopharm 116:102-110, DOI 10.1016/j.ejpb.2016.12.018

Colombo M, Staufenbiel S, Rühl E, Bodmeier R 2017. In situ determination of the saturation solubility of nanocrystals of poorly soluble drugs for dermal application. Int J Pharm 531:156-166 DOI 10.1016/j.ijpharm.2017.02.030

Colombo M, Orthmann S, Bellini M, Staufenbiel S, Bodmeier R 2017. Influence of drug brittleness, nanomilling time, and freeze-drying on the crystallinity of poorly water-soluble drugs and its implications for solubility enhancement. AAPS PharmSciTech 18(7): 2437-2445 DOI 10.1208/s12249-017-0722-4

Balzus B, Sahle FF, Hönzke S, Gerecke C, Schumacher F, Hedtrich S, Kleuser B, Bodmeier R 2017. Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium. Eur J Pharm Biopharm 115:122-130 DOI 10.1016/j.ejpb.2017.02.001

Alexiev U, Volz P, Boreham A, Brodwolf R 2017. Time-resolved fluorescence microscopy (FLIM) as an analytical tool in skin nanomedicine. Eur J Pharm Biopharm 116:111-124 DOI 10.1016/j.ejpb.2017.02.005 (Review)

Mohammadifar E, Adeli M, Nemati Kharat A, Namazid H, Haag R 2017. Stimuli-responsive core multi-shell dendritic nanocarriers. Macromol Chem Phys 218:1600525 (7 pages) DOI 10.1002/macp.201600525

Radbruch M, Pischon H, Ostrowski A, Volz P, Brodwolf R, Neumann F, Unbehauen M, Kleuser B, Haag R, Ma N, Alexiev U, Mundhenk L, Gruber AD 2017. Dendritic core-multishell nanocarriers in murine models of healthy and atopic skin. Nanoscale Res Lett 12:64 DOI 10.1186/s11671-017-1835-0 (online publication, 12 pages)

Mohammadifar E, Bodaghi A, Dadkhahtehrani A, Kharat AN, Adeli M, Haag R 2017. Green synthesis of hyperbranched polyglycerol at room temperature. ACS Macro Lett 6:35-40 DOI 10.1021/acsmacrolett.6b00804

Patzelt A, Mak WC, Jung S, Knorr F, Meinke MC, Richter H, Rühl E, Cheung KY, Tran NBNN, Lademann J 2017. Do nanoparticles have a future in dermal drug delivery? J Control Release 246: 174-182, DOI 10.1016/j.jconrel.2016.09.015

Rimondino GH, Miceli E, Molina M, Wedepohl S, Thierbach S, Rühl E, Strumia M, Martinelli M, Calderón M 2017. Rational design of dendritic thermo-responsive nanogels that undergo phase transition on endolysosomal conditions. J  Mat Chem B 5:866-874, DOI 10.1039/C6TB02001A

Liese S, Gensler M, Krysiak S, Schwarzl R, Achazi A, Paulus B, Huge T, Rabe JP, Netz RR 2017. Hydration effects turn a highly stretched polymer from an entropic into an energetic spring. ACS Nano 11:702-712 DOI 10.1021/acsnano.6b07071

Sahle FFGiulbudagian M, Bergueiro J, Lademann JCalderón M 2017. Dendritic polyglycerol and N-isopropylacrylamide based thermoresponsive nanogels as smart carriers for controlled delivery of drugs through the hair follicle. Nanoscale 9:172-182 DOI 10.1039/C6NR06435C

Sahle FFGerecke CKleuser BBodmeier R 2017. Formulation and comparative in vitro evaluation of various dexamethasone-loaded pH-sensitive polymeric nanoparticles intended for dermal applications. Int J Pharm 516:21-31 DOI 10.1016/J.ijpharm.2016.11.029

Boreham AVolz P, Peters D, Keck CM, Alexiev U 2017. Determination of nanostructures and drug distribution in lipid nanoparticles by single molecule microscopyEur J Pharm Biopharm 110:31-38 DOI 10.1016/j.ejpb.2016.10.020 

Zoubari G, Staufenbiel S, Volz PAlexiev U, Bodmeier R 2017. Effect of drug solubility and lipid carrier on drug release from lipid nanoparticles for dermal delivery. Eur J Pharm Biopharm 110:39-46 DOI 10.1016/j.ejpb.2016.10.021

Pischon H, Radbruch M, Ostrowski A, Volz P, Gerecke C, Unbehauen M, Hönzke S, Hedtrich S, Fluhr JW, Haag R, Kleuser B, Alexiev U, Gruber AD, Mundhenk L 2017. Stratum corneum targeting by dendritic core-multishell-nanocarriers in a mouse model of psoriasis. Nanomedicine: NBM 13:317-327 DOI 10.1016/j.nano.2016.09.004

Dimde M, Steinhilber D, Neumann F, Li Y, Paulus FMa NHaag R 2017. Synthesis of pH-Cleavable dPG-Amines for Gene Delivery Application. Macromol Biosci 17:1616-5195, DOI 10.1002/mabi.201600190

Lohan SB, Saeidpour S, Solik A, Schanzer S, Richter H, Dong P, Darvin ME, Bodmeier R, Patzelt A, Zoubari G, Unbehauen M, Haag R, Lademann J, Teutloff C, Bittl R, Meinke MC 2017. Investigation of the cutaneous penetration behavior of dexamethasone loaded to nano-sized lipid particles by EPR spectroscopy, and confocal Raman and Laser scanning microscopy. Eur J Pharm Biopharm 116:102-110 DOI 10.1016/j.ejpb.2016.12.018

Löwenau LJ, Zoschke C, Brodwolf R, Volz P, Hausmann C, Wattanapitayakul S, Boreham A, Alexiev U, Schäfer-Korting M 2017. Increased permeability of reconstructed human epidermis from UVB-irradiated keratinocytes.  Eur J Pharm Biopharm 116:149-154 DOI 10.1016/j.ejpb.2016.12.017

Edlich A, Gerecke C, Giulbudagian M, Neumann F, Hedtrich S, Schäfer-Korting M, Ma N, Calderón M, Kleuser B 2017. Specific uptake mechanisms of well-tolerated thermoresponsive polyglycerol-based nanogels in antigen-presenting cells of the skin. Eur J Pharm Biopharm 116:155-163 DOI 10.1016/j.ejpb.2016.12.016

Schwarzl R, Du F, Haag R, Netz RR 2017. General method for the quantification of drug loading and release kinetics of nanocarriers. Eur J Pharm Biopharm 116:131-137 DOI 10.1016/j.ejpb.2016.12.015

Döge N, Avetisyan A, Hadam S, Pfannes EKB, Rancan F, Blume-Peytavi U, Vogt A 2017. Assessment of skin barrier function and biochemical changes of ex vivo human skin in response to physical and chemical barrier disruption. Eur J Pharm Biopharm 116:138-148 DOI 10.1016/j.ejpb.2016.12.012

Müller F, Hönzke S, Luthardt W-O, Wong EL, Unbehauen M, Bauer J, Haag R, Hedtrich S, Rühl E, Rademann J 2017. Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery. Eur J Pharm Biopharm 116:31-37DOI 10.1016/j.ejpb.2016.12.013

Yamamoto K, Klossek A, Flesch R, Rancan F, Weigand M, Bykova I,Bechtel M, Ahlberg S, Vogt A, Blume-Peytavi U, Schrade P, Bachmann S, Hedtrich S, Schäfer-Korting M, Rühl E 2017. Influence of the skin barrier on the penetration of topically-applied dexamethasone probed by soft X-ray spectromicroscopy. Accepted for publication in: Eur J Pharm Biopharm 118:30-37 DOI 10.1016/j.ejpb.2016.12.005

Rancan F, Giulbudagian M, Jurisch J, Blume-Peytavi U, Calderón M, Vogt A 2017. Drug delivery across intact and disrupted skin barrier: identification of cell populations interacting with penetrated thermoresponsive nanogels. Eur J Pharm Biopharm 116:4-11 DOI 10.1016/j.ejpb.2016.11.017 

Klossek A, Thierbach S, Rancan F, Vogt A, Blume-Peytavi U, Rühl E 2017. Studies for improved understanding of lipid distributions in human skin by combining stimulated and spontaneous Raman microscopy. Eur J Pharm Biopharm 116:76-84 DOI 10.1016/j.ejpb.2016.11.001 

Brunacci N, Wischke C, Naolou TNeffe ATLendlein A 2017. Influence of surfactants on depsipeptide submicron particle formation. Eur J Pharm Biopharm 116:61-65 DOI 10.1016/j.ejpb.2016.11.011 

Radtke MPatzelt AKnorr FLademann JNetz RR 2017. Ratchet effect for nanoparticle transport in hair follicles. Eur J Pharm Biopharm 116:125-130 DOI 10.1016/j.ejpb.2016.10.005 

Chen W, Hou Y, Tu Z, Gao LHaag R 2017. pH-degradable PVA-based nanogels via photo-crosslinking of thermo-preinduced nanoaggregates for controlled drug delivery. J Contr Release 259:160-167 DOI 10.1016/j.jconrel.2016.10.032 

Zhang NSaid A, Wischke C, Kral V, Brodwolf R, Volz PBoreham AGerecke CLi WNeffe ATKleuser BAlexiev ULendlein ASchäfer-Korting M 2017. Poly[acrylonitrile-co-(N-vinyl pyrrolidone)] nanoparticles - composition-dependent skin penetration enhancement of a dye probe and biocompatibility. Eur J Pharm Biopharm 116:66-75 DOI 10.1016/j.ejpb.2016.10.019

Saeidpour SLohan SB, Anske M, Unbehauen M, Fleige E, Haag RMeinke MCBittl RTeutloff C 2017. Localization of dexamethasone within dendritic core-multishell (CMS) nanoparticles and skin penetration properties studied by multi-frequency electron paramagnetic resonance spectroscopy (EPR). Eur J Pharm Biopharm 116:94-101 DOI 10.1016/j.ejpb.2016.10.001

Balk M, Behl M, Yang J, Li Q, Wischke C, Feng Y, Lendlein A 2017. Design of polycationic micelles by self-assembly of polyethyleneimine functionalized oligo[(ε-caprolactone)-co-glycolide] ABA block copolymers. Polymer Adv Tech 28(10): 1278-1284 DOI 10.1002/pat.3911

Tran NBNN, Knorr F, Mak WC, Cheung KY, Richter HMeinke MLademann JPatzelt A 2017. Gradient-dependent release of the model drug TRITC-dextran from FITC-labeled BSA hydrogel nanocarriers in the hair follicles of porcine ear skin. Eur J Pharm Biopharm 116:12-16  DOI 10.1016/j.ejpb.2016.2016.09.016


(in chronologischer Reihenfolge)

Asadian-Birjand M, Biglione C, Bergueiro J, Cappelletti A, Rahane C, Chate G, Khandare J, Klemke B, Strumia MC, Calderón M 2016. Transferrin decorated thermoresponsive nanogels as magnetic trap devices for circulating tumor cells. Macromol Rapid Commun 37:439-445 DOI 10.1002/marc.201500590

Radtke MNetz RR 2016. Ratchet effect for two-dimensional nanoparticle motion in a corrugated oscillating channel. Eur Phys J E 39:116 DOI 10.1140/epje/i2016-16116-4 

Giulbudagian MRancan FKlossek AYamamoto K, Jurisch J, Colombo Neto V, Schrade P, Bachmann S, Rühl EBlume-Peytavi UVogt ACalderón M 2016. Correlation between the chemical composition of thermoresponsive nanogels and their interaction with the skin barrier. J Contr Release 243:323-332 DOI 10.1016/j.jconrel.2016.10.022 

Saeidpour S, Lohan SB, Solik A, Paul V, Bodmeier R, Zoubari G, Unbehauen M, Haag R, Bittl R, Meinke MC, Teutloff C 2016. Drug distribution in nanostructured lipid particles. Eur J Pharm Biopharm 110:19-23 DOI 10.1016/j.ejpb.2016.10.008

Naolou TLendlein ANeffe AT 2016. Influence of metal softness on the metal-organic catalyzed polymerization of morpholin-2,5-diones to oligodepsipeptides. Eur Polym J 85:139-149 DOI 10.1016/j.eurpolymj.2016.10.011 

Zhong YDimde M, Stöbener D, Meng F, Deng C, Zhong Z, Haag R 2016. Micelles with sheddable dendritic polyglycerol sulfate shells show extraordinary tumor targetability and chemotherapy in vivo. ACS Appl Mater Interfaces 8:27530-27538 DOI 10.1021/adxami.6b09204

Balzus BColombo M, Sahle FFZoubari G, Staufenbiel S, Bodmeier R 2016. Comparison of different in vitro release methods used to investigate nanocarriers intended for dermal application. Int J Pharm 513:247-254 DOI 10.1016/jijpharm.2016.09.33 

Yamamoto KKlossek AFlesch R, Ohigashi T, Fleige ERancan F, Frombach J, Vogt ABlume-Peytavi U, Schrade P,  Bachmann S, Haag RHedtrich S, Schäfer-Korting M, Kosugi N, Rühl E 2016. Core-multishell nanocarriers: Transport and release of dexamethasone probed by soft X-ray spectromicroscopy. J Control Release 242:64-70 DOI 10.1016/j.jconrel.2016.08.028 

Wang W, Balk M, Deng Z, Wischke C, Gossen M, Behl M, Ma NLendlein A 2016. Engineering biodegradable micelles of polyethylenimine-based amphiphilic block copolymers for efficient DNA and siRNA delivery. J Control Release 242:71-79 DOI 10.1016/j.jconrel.2016.08.004 

Kanduc MSchlaich A, Schneck E, Netz RR 2016. Water-mediated interactions between hydrophilic and hydrophobic surfaces. Langmuir 32:8767-8782 DOI 10.1021/acs.langmuir.6b01727 

Zabihi F, Wieczorek S, Dimde MHedtrich S, Börner HG, Haag R 2016. Intradermal drug delivery by nanogel-peptide conjugates; specific and efficient transport of temoporfin. J Control Release 242:35-41 DOI 10.1016/j.jconrel.2016.07.033 

Wischke C, Rühl ELendlein A 2016. Dermal Drug Delivery by Nanocarriers. J Control Release 242:1-2 DOI 10.1016/j.jconrel.2016.10.025 

Vogt AWischke CNeffe ATMa NAlexiev ULendlein A 2016. Nanocarriers for drug delivery into and through the skin - do existing technologies match clinical challenges? J Control Release 242:3-15 DOI 10.1016/j.jconrel.2016.07.027 (Review) 

Thota DGS, Urner L, Haag R 2016. Supramolecular architectures of dendritic amphiphiles in water. Chem Rev 116:2079-2102 DOI: 10.1021/acs.chemrev.5b00417 (Review)

Döge NHönzke SSchumacher FBalzus BColombo MHadam SRancan FBlume-Peytavi USchäfer-Korting MSchindler ARühl E, Stahl Skov P, Church M, Hedtrich SKleuser BBodmeier RVogt A 2016. Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivohuman skin -assessment by intradermal microdialysis and extraction from the different skin layers. J Control Release, 242:25-34 DOI 10.1016/j.jconrel.2016.07.009 

Sahle FFBalzus BGerecke CKleuser BBodmeier R 2016. Formulation and in vitro evaluation of polymeric enteric nanoparticles as dermal carriers with pH-dependent targeting potential. Eur J Pharm Sci 92:98-109 DOI 10.1016/j.ejps.2016.07.004 

Du FHönzke SNeumann F, Keilitz J, Chen WMa NHedtrich SHaag R 2016. Development of biodegradable hyperbranched core-multishell nanocarriers for efficient topical drug delivery. J Control Release 242:42-49 DOI 10.1016/j.jconrel.2016.06.048 

Hönzke SGerecke CElpelt A, Zhang N, Unbehauen MKral V, Fleige E, Paulus FHaag RSchäfer-Korting MKleuser BHedtrich S 2016. Tailored dendritic core-multishell nanocarriers for efficient dermal drug delivery: A systematic top-down approach from synthesis to preclinical testing. J Control Release 242:50-63. DOI 10.1016/j.jconrel.2016.06.030 

Volz P, Krause N, Balke J, Schneider C, Walter M, Schneider F, Schlesinger R, Alexiev U 2016. Light and pH-induced changes in structure and accessibility of transmembrane helix B and its immediate environment in Channelrhodopsin-2. J Biol Chem 291:17382-17393, DOI 10.1074/jbc.M115.711200 

Dong C, Liu Z, Liu J, W C, Neumann F, Wang H, Schäfer-Korting MKleuser B, Chang J, Li W, Ma NHaag R 2016. A highly photostable hyperbranched polyglycerol-based NIR fluorescence nanoplatform for mitochondria-specific cell imaging. Adv Healthcare Mater 5:2214-2226 DOI 10.1002/adhm.201600212 

Wischke C, Lendlein A 2016. Functional nanocarriers by miniaturization of polymeric materials. Nanomedicine 11:1507-1509 DOI 10.2217/nnm.16.45 

Ahlberg SRancan F, Epple M, Loza K, Höppe D, Lademann JVogt AKleuser BGerecke CMeinke MC 2016. Comparison of different methods to study effects of silver nanoparticles on the pro- and antioxicant status of human keratinocytes and fibroblasts. Methods 109:55-63 DOI 10.1016/j.ymeth.2016.05.015 

Walker K, Stumbé J-F, Haag R 2016. Polyester-based, biodegradable core-multishell nanocarriers for the transport of hydrophobic drugs. Polymers 8(5):192(24 pages) DOI 10.3390/polym8050192 

Stefani S, Sharma SK, Haag R, Servin P 2016. Core-shell nanocarriers based on PEGylated hydrophobic hyperbranched polyesters. Eur Polym J 80:158-168 DOI 10.1016/j.eurpolymj.2016.05.005 

Stefani SHönzke S, Cuellar Camach JL, Neumann F, Prasad AK, Hedtrich SHaag R, Servin P 2016. Hyperbranched glycerol-based core-amphiphilic branched shell nanotransproters for dermal drug delivery. Polymer 96:156-166 DOI 10.1016/j.polymer.2016.04.074 

Hansing J, Ciemer C, Kim WK, Zhang X, DeRouchey JE, Netz RR 2016. Nanoparticle filtering in charged hydrogels: Effects of particle size, charge asymmetry and salt concentration. Eur J Phys J E 39(5):53(13 pages) DOI 10.1140/epje/i2016-16053-2

Knorr FPatzelt A, Darvin ME, Lehr C-M, Schäfer U, Gruber ADOstrowski ALademann J 2016. Penetration of topically applied nanocarriers into the hair follicles of dog and rat dorsal skin and porcine ear skin. Vet Dermatol 27(4):256-E60 DOI: 10.1111/vde.12325 

Rancan F, Asadian-Birjand M, Dogan S, Graf C, Cuellar L, Lommatzsch S, Blume-Peytavi UCalderón MVogt A 2016. Effects of thermoresponsivity and softness of polyglycerol-based nanogels on skin penetration and cellular uptake. J Control Rel 228:159-169 DOI 10.1016/j.jconrel.2016.02.047 

Lohan SB, Icken N, Teutloff CSaeidpour SBittl RLademann JFleige EHaag R, Haag SF, Meinke MC 2016. Investigation of cutaneous penetration properties of stearic acid loaded to dendritic core-mulit-shell (CMS) nanocarriers. Int J Pharm 501:271-277 DOI 10.1016/j.ijpharm.2016.02.004 

Patoka P, Ulrich G, Nguyen AE, Bartels L, Dowben PA, Turkowski V, Rahman TS, Hermann P, Kästner B, Hoehl A, Ulma G, Rühl E 2016. Nanoscale plasmonic phenomena in CVD-grown MoS2 monolayer revealed by ultra-broadband synchrotron radiation based nano-FTIR spectroscopy and near-field microscopy. Opt Express 24:1154-1164 DOI 10.1364/OE.24.001154 

Boreham A, Pikkemaat J, Volz P, Brodwolf R, Kuehne C, Licha K, Haag R, Dernedde J, Alexiev U 2016. Detecting and quantifying biomolecular interactions of a dendritic polyglycerol sulfate nanoparticle using fluorescence lifetime measurements. Molecules 21(1):22(13 pages) DOI 10.3390/molecules21010022  

Lademann J, Richter H, Knorr FPatzelt A, Darvin ME, Rühl E, Cheung KY, Lai KK, Renneberg R, Mak WC 2016.  Triggered release of model drug from FITC-AuNP-doped BSA nanocarriers in hair follicles using IRA radiation. Acta Biomater 30:388-396 DOI 10.1016/j.actbio.2015.11.052 

Gutiérrez V, Seabra AB, Reguera RM, Khandared J, Calderón M 2016. New approaches from nanomedicine for treating leishmaniasis. Chem Soc Rev 45:152-168 DOI 10.1039/c5cs00674k


(in chronologischer Reihenfolge)

Stefani S, Kurniasih IN, Sharma SK, Böttcher C, Haag R, Servin P 2015. Triglycerol-based hyperbranched polyesters with an amphiphilic branched shell as novel biodegradable drug delivery systems. Polym Chem 7:887-898 DOI 10.1039/c5py01314c 

Hönzke S, Wallmeyer L, Ostrowski A, Radbruch M, Mundhenk L, Schäfer-Korting M, Hedtrich S 2015. Influence of Th2 cytokines on the cornified envelope, tight junction proteins and ß-defensins in filaggrin-deficient skin models. J Invest Dermatol 136:631-639 DOI 10.1016/j.jid.2015.11.007 

Richter C, Schneider C, Quick MT, Volz P, Mahrwald R, Hughes J, Dick B, Alexiev U, Ernsting NP 2015. Dual-fluorescence pH probe for bio-labelling. Phys Chem Chem Phys 17:30590-30597 DOI 10.1039/c5cp05454k 

Kowalik B, Schubert T, Wada H, Tanaka M, Netz R, Schneck E 2015. Combination of MD Simulations withTwo-State Kinetic Rate Modeling Elucidatesthe Chain Melting Transition of PhospholipidBilayers for Different Hydration Levels. J Phys Chem B  119:14157-14167 DOI 10.1021/acs.jpcb.5b05501 

Asadian-Birjand M, Bergueiro J, Rancan F, Cuggino JC, Mutihac RC, Achazi K, Derneddle J, Blume-Peytavi U, Vogt A, Calderón M 2015. Engineering thermoresponsive polyether-based nanogels for temperature dependent skin penetration.  Polym Chem 6:5827-5831 DOI 10.1039/c5py00924c 

Molina M, Asadian-Birjand M, Balach J, Bergueiro J, Miceli E, Calderón M 2015. Stimuli-responsive nanogel composites and their application in nanomedicine. Chem Soc Rev 44:6161-6186 DOI 10.1039/c5cs00199d (Review) 

Kurniasih IN, Keilitz J, Haag R 2015. Dendritic nanocarriers based on hyperbranched polymers. Chem Soc Rev 44:4145-4164 DOI 10.1039/c4cs00333k (Review) 

Chen W, Achazi K, Schade B, Haag R 2015. Charge-conversional and reduction-sensitive poly(vinyl alcohol) nanogels for enhanced cell uptake and efficient intracellular doxorubicin release. J Control Release, 205:15-24 DOI 10.1016/j.jconrel.2014.11.012 

Yamamoto K, Flesch R, Ohigashi T, Hedtrich S, Klossek A, Patoka P, Ulrich G, Ahlberg S, Rancan FVogt A, Blume-Peytavi U, Schrade P, Bachmann S, Schäfer-Korting M, Kosugi N, Rühl E 2015. Selective probing of the penetration of dexamethasone into human skin by soft-X-ray spectromicroscopy. Anal Chem 87:6173-6179 DOI 10.1021/acs.analchem.5b00800 

Zoschke C, Schilrreff P, Romero EL, Brandner JM, Schäfer-Korting M 2015. Dendritic Nanoparticles for Cutaneous Drug Delivery - Testing in Human Skin and Reconstructed Human Skin. Curr Pharm Des 21:2784-2800 DOI 10.2174/1381612821666150428142515 

Witting M, Boreham A, Brodwolf R, Vávrová K, Alexiev U, Friess W, Hedtrich S 2015. Interactions of hyaluronic acid with the skin and implications for the dermal delivery of biomacromolecules. Mol Pharm 12:1391-1401 DOI 10.1021/mp500676e 

Volz P, Boreham A, Wolf A, Kim T-Y, Balke J, Frombach J, Hadam S, Afraz Z, Rancan F, Blume-Peytavi U, Vogt A, Alexiev U 2015. Application of single molecule fluorescence microscopy to characterize the penetration of a large amphiphilic molecule in the stratum corneum of human skin. Int J Mol Sci 16:6960-6977 DOI 10.3390/ijms16046960 

Witting M, Molina M, Obst K, Plank R, Eckl KM, Hennies HC, Calderón M, Frieß W, Hedtrich S 2015. Thermoresponsive hyperbranched polyglycerol nanogels for cutaneous drug delivery of biomacromolecules. Nanomedicine: NBM 11:1179-1187 DOI 10.1016/j.nano.2015.02.017 

Graf C, Nordmeyer D, Ahlberg S, Raabe J, Vogt A, Lademann J, Rancan F, Rühl E 2015. Penetration of spherical and rod-like gold nanoparticles into intact and barrier- disrupted human skin. Proc SPIE 9338, 93381L-1. DOI 10.1117/12.2079719 

Holzhausen C, Gröger D, Mundhenk L, Donat CL,  Schnorr J, Haag R, Gruber AD 2015. Biodistribution, cellular localization and in vivo tolerability of 35S-labeled antiinflammatory dendritic polyglycerol sulfate amine. J Nanoparticle Res 17:116 DOI 10.1007/s11051-015-2927-3 

Witting M, Obst K, Friess W, Hedtrich S 2015. Recent Advances in Topical Delivery of Proteins and Peptides Mediated by Soft Matter Nanocarriers. Biotechnological Advances 33:1355-1369 DOI 10.1016/j.biotechadv.2015.01.010 (Review) 

Molina M, Bergueiro J, Sousa-Hervés A, Calderón M 2015. Aplicaciones biomédicas de nanogeles dendríticos termosensibles. Rev Iber Polimeros 16:164-172 ISSN-e 0121-6651

Zhang X, Hansing J, Netz RR, DeRouchey JE 2015. Particle transport through hydrogels is charge asymmetric. Biophys J 108:530-539 DOI 10.1016/j.bpj.2014.12.009 

Biglione C, Sousa-Herves A, Menger M, Wedepohl S, Calderón M, Strumia MC 2015. Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels. RSC Adv 5:15407 DOI 10.1039/c4ra15784b 

Adeli M, Namazi H, Du F, Hönzke S, Hedtrich S, Keilitz J, Haag R 2015. Synthesis of multiarm star copolymers based on polyglycerol cores with polylactide arms and their application as nanocarriers. RSC Adv 5:14958-14966 DOI 10.1039/c4ra14619k 

Ostrowski A, Nordmeyer D, Boreham A, Holzhausen C, Mundhenk L, Graf C, Meinke M, Vogt A, Haddam S, Lademann J, Rühl R, Alexiev U, Gruber AD 2015. Overview on the Localization of Nanoparticles in Tissue and Cellular Context by Different Imaging Techniques. (Review) Beilstein J Nanotechnol 6:263-280 DOI 10.3762/bjnano.6.25 

Lukowiak MC, Ziem B, Achazi K, Gunkel-Grabole G, Popeney CS, Thota BNS, Böttcher C, Krueger A, Guan Z, Haag R 2015. Carbon-based cores with polyglycerol shells - the importance of core flexibility for encapsulation of hydrophobic guests. J Mater Chem B 3:719-722 DOI 10.1039/c4tb01858c 

Lohan SB, Bauersachs S, Ahlberg S, Baisaeng N, Keck CM, Müller RH, Witte E, Wolk K, Hackbarth S, Röder B, Lademann J, Meinke MC 2015. Ultra-small lipid nanoparticles promote the penetration of coenzyme Q10 in skin cells and counteract oxidative stress. Eur J Pharm Biopharm 89:201-207 DOI 10.1016/j.ejpb.2014.12.008 

Lademann J, Knorr F, Richter H, Jung S, Meinke MC, Rühl E, Alexiev U, Calderón M, Patzelt A 2015. Hair follicles as a target structure for nanoparticles. J Innov Opt Health Sci 8:530004(8 pages) DOI 10.1142/S1793545815300049 

Henry B, Neill D, Becker K, Gore S, Bricio-Moreno L, Ziobro R, Edwards MJ, Mühlemann K, Steinmann J, Kleuser B, Japtok L, Luginbühl M, Wolfmeier H, Scherag A, Gulbins E, Kadioglu A, Draeger A, Babiychuk E 2015. Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nature Biotechnology 33:81-88 DOI 10.1038/nbt.3037 

Zhu Y, Choe C-S, Ahlberg S, Meinke MC, Alexiev U, Lademann J, Darvin ME 2015. Penetration of silver nanoparticles into porcine skin ex vivo using fluorescence lifetime imaging microscopy, Raman microscopy, and surface-enhanced Raman scattering microscopy. J Biomed Opt 20(5):051006(8 pages) DOI 10.1117/1.JBO.20.5.051006 

Schlaich A, Kowalik B, Kanduc M, Schneck E, Netz RR 2015. Physical mechanisms of the interaction between lipid membranes in the aqueous environment. Physica A 418:105-125 DOI 10.1016/j.physa.2014.06.088


Schäfer-Korting M, Romero EL. Core-shell nanotransporters for the skin.
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(in alphabetischer Reihenfolge)

Alnasif N, Zoschke C, Fleige E, Brodwolf R, Boreham A, Rühl E, Eckl KM, Merk HF, Hennies HC, Alexiev U, Haag R, Küchler S, Schäfer-Korting M 2014. Penetration of normal, damaged and diseased skin - An in vitro study on dendritic core-multishell nanotransporters. J Control Release 185:45-50 DOI 10.1016/j.jconrel.2014.04.006.

Bergueiro J, Calderón M 2014. Thermoresponsive Nanodevices in Biomedical Applications. Macromol Biosci 15:183-199 DOI 10.1002/mabi.201400362

Boreham A, Pfaff M, Fleige E, Haag R, Alexiev U 2014. Nanodynamics of dendritic core-multishell nanocarriers. Langmuir 30:1686-1695 DOI 10.1021/la4043155

Boreham A, Brodwolf R, Pfaff M, Kim T-Y, Schlieter T, Mundhenk L, Gruber AD, Gröger D, Licha K, Haag R, Alexiev U 2014. Temperature and environment dependent dynamic properties of a dendritic polyglycerol sulfate. Polym Adv Technol 25:1329-1336 DOI 10.1002/pat.3355

Fleige E, Achazi K, Schaletzki K, Triemer T, Haag R 2014. pH-Responsive Dendritic Core-Multishell Nanocarriers. J Control Release 185:99-108 DOI 10.1016/j.jconrel.2014.04.019

Giulbudagian M, Asadian-Birjand M, Steinhilber D, Achazi K, Molina M, Calderón M 2014. Fabrication of thermoresponsive nanogels by thermo-nanoprecipitation and in situ encapsulation of bioactives. Polym Chem 5:6909-6913 DOI 10.1039/C4PY01186D (highlighted as back cover)

Hermann P, Hoehl A, Ulrich G, Fleischmann C, Hermelink A,  Kästner B, Patoka P, Hornemann A, Beckhoff B, Rühl E, Ulm G 2014. Characterization of Semiconductor Samples using Synchrotron Radiation-based Near-Field Infrared Microscopy and Nano-FTIR Spectroscopy. Opt Express 22:17948–17958 DOI 10.1364/OE.22.017948

Lademann J, Richter H, Baier G, Landfester K, Frazier L, Gefeller H, Wunderlich U, Gross I, Rühl E, Knorr F 2014. Decontamination of skin exposed to nanocarriers using an absorbent textile material and PEG-12 dimethicone. Laser Phys Lett 11(11):115603(4 pages) DOI 10.1088/1612-2011/11/11/115603

Molina M, Giulbudagian M, Calderón M 2014. Positively Charged Thermoresponsive Nanogels for Anticancer Drug Delivery. Macromol Chem Phys 215:2414-2419 DOI 10.1002/macp.201400286

Nafisi S, Schäfer-Korting M, Maibach H 2014. Perspectives on percutaneous penetration: Silica nanoparticles. Nanotoxicology 9:643-657 DOI 10.3109/17435390.2014.958115 (Review)

Nowag S, Haag R 2014. pH-responsive micro- and nanocarrier systems. Angew Chem Int Ed 53:49-51 DOI 10.1002/anie.201308619 (Review)

Nowag S, Frangville C, Multhaup G, Marty J-D, Mingotaud C, Haag R 2014. Biocompatible, hyperbranched nanocarriers for the transport and release of copper ions. J Mater Chem B 2:3915-3918 DOI 10.1039/c4tb00454j

Ostrowski A, Nordmeyer D, Boreham A, Brodwolf R, Mundhenk L, Fluhr JW, Lademann J, Graf C, Rühl E, Alexiev U, Gruber AD 2014. Skin barrier disruptions in tape stripped and allergic dermatitis models have no effect on dermal penetration and systemic distribution of AHAPS-functionalized silica nanoparticles. Nanomedicine 10:1571-1581 DOI 10.1016/j.nano.2014.04.004

Ostrowski A, Nordmeyer N, Mundhenk L, Fluhr JW, Lademann J, Graf C, Rühl E, Gruber AD 2014. AHAPS-functionalized silica nanoparticles do not modulate allergic 2 contact dermatitis in mice. Nanoscale Research Letters 9:524(7 pages) DOI 10.1186/1556-276X-9-524 

Rabe C, Fleige E, Vogtt K, Szekely N, Lindner P, Burchard W, Haag R, Ballauff M 2014. The mulit-domain nanoparticle structure of a universal core-multishell nanocarrier. Polymer 55:6735-6742 DOI 10.1016/j.polymer.2014.10.061

Rancan F, Blume-Peytavi U, Vogt A 2014. Utilization of biodegradable polymeric materials as delivery agents in dermatology. Clin Cosmet Investig Dermatol 7:23-34 DOI 10.2147/CCID.S39559 (Review)

Richter M, Steinhilber D, Haag R, von Klitzing R 2014. Visualization of real time degradation of pH-responsive polyglycerol nanogels via atomic force microscopy. Macromol Rapid Comm 35:2018-2022 DOI 10.1002/marc.201400449

Vávrová K, Henkes D, Sochorová M, Sklová B, Stüver K, Witting M, Friess W, Schreml S, Meier RJ, Schäfer-Korting M, Fluhr J, Küchler S 2014. Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct. J Invest dermatol 134:746-753 DOI 10.1038/jid.2013.402

Vogt A, Blume-Peytavi U 2014. Selective hair therapy: bringing science to the fiction. Experimental Dermatology 23:83-86  DOI 10.1111/exd.12318

Wang W, Xu X, Li Z, Ledlein A, Ma N 2014. Genetic engineering of mesenchymal stem cells by non-viral gene delivery. Clin Hemorheol Microcirc 58:19-48 DOI 10.3233/CH-141883

Weber M, Zoschke C, Sedighi A, Fleige E, Haag R, Schäfer-Korting M 2014. Free Energy Simulations of Cargo-Carrier Interactions for Core-Multishell Nanotransporters. J Nanomed Nanotechnol 5:100234(5 pages) DOI 10.4172/2157-7439.1000234


Steinhilber D, Rossow T, Wedepohl S, Paulus F, Seiffert S, Haag R 2013. A microgel construction kit for bioorthogonal encapsulation and pH-controlled release of living cells. Angew Chem Int Ed 52:13538-13543 DOI 10.1002/anie.201308005