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Anja Ostrowski, Ph.D., Tierärztin

ehemalige assoziierte Doktorandin und Postdoktorandin, Elternzeitvertretung
Arbeitsgruppe Prof. Dr. A. Gruber (TP C03)
Institut für Tierpathologie
Fachbereich Veterinärmedizin
Freie Universität Berlin


Nanocarriers in the skin of mouse models: Penetration, effects of barrier dysfunction in diseased skin and improved targeting of inflammation

Erstbetreuer:                           Prof. Dr. Achim Gruber

Dissertation abgeschlossen im Dezember 2014

FB 1112-Publikationen:

Pischon H, Radbruch M, Ostrowski A, Schumacher F, Hönzke S, Kleuser B, Hedtrich S, Fluhr JW, Gruber AD, Mundhenk L 2017. How effective is tacrolimus in the imiquimod-induced mouse model of psoriasis? J Invest Dermatol. Epub ahead of print. DOI 10.1016/j.jid.2017.09.019

Pischon H, Radbruch M, Ostrowski A, Volz P, Gerecke C, Unbehauen M, Hönzke S, Hedtrich S, Fluhr JW, Haag R, Kleuser B, Alexiev U, Gruber AD, Mundhenk L 2016. Stratum corneum targeting by dendritic core-multishell-nanocarriers in a mouse model of psoriasis. Nanomedicine: NBM 13:317-327 DOI 10.1016/j.nano.2016.09.004

Radbruch M, Pischon H, Ostrowski A, Volz P, Brodwolf R, Neumann F, Unbehauen M, Kleuser B, Haag R, Ma N, Alexiev U, Mundhenk L, Gruber AD 2017. Dendritic core-multishell nanocarriers in murine models of healthy and atopic skin. Nanoscale Res Lett 12:64 DOI 10.1186/s11671-017-1835-0 (online publication, 12 pages)

Knorr F, Patzelt A, Darvin ME, Lehr C-M, Schäfer U, Gruber AD, Ostrowski A, Lademann J 2016. Penetration of topically applied nanocarriers into the hair follicles of dog and rat dorsal skin and porcine ear skin. Vet Dermatol 27:256-e60 DOI 10.1111/vde.12325

Hönzke S, Wallmeyer L, Ostrowski A, Radbruch M, Mundhenk L, Schäfer-Korting M, Hedtrich S 2015. Influence of Th2 cytokines on the cornified envelope, tight junction proteins and ß-defensins in filaggrin-deficient skin models. J Invest Dermatol 136:631-639DOI 10.1016/j.jid.2015.11.007 (ROSA-Award, Forschungspreis Atopische Dermatitis 2016, La Roche-Posay)

Ostrowski A, Nordmeyer D, Boreham A, Holzhausen C, Mundhenk L, Graf C, Meinke M, Vogt A, Haddam S, Lademann J, Rühl R, Alexiev U, Gruber AD 2015. Overview on the Localization of Nanoparticles in Tissue and Cellular Context by Different Imaging Techniques. (Review) Beilstein J Nanotech 6:263-280 DOI10.3762/bjnano.6.25 (epub)

Ostrowski A, Nordmeyer D, Boreham A, Brodwolf R, Mundhenk L, Fluhr JW, Lademann J, Graf C, Rühl E, Alexiev U, Gruber AD 2014. Skin barrier disruptions in tape stripped and allergic dermatitis models have no effect on dermal penetration and systemic distribution of AHAPS-functionalized silica nanoparticles. Nanomedicine 10:1571-1581. DOI 10.1016/j.nano.2014.04.004

Ostrowski A, Nordmeyer N, Mundhenk L, Fluhr JW, Lademann J, Graf C, Rühl E, Gruber AD 2014. AHAPS-functionalized silica nanoparticles do not modulate allergic 2 contact dermatitis in mice. Nanoscale Research Letters 9:524 DOI 10.1186/1556-276X-9-524 (epublication, 7 pages)