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Michael Unbehauen, Dipl.-NanoSc.

Doktorand und Stipendiat des IRTG "Nanocarrier" in der Arbeitsgruppe Prof. Dr. Rainer Haag (TP A02)
Organische Chemie
Institut für Chemie und Biochemie
Fachbereich Biologie, Chemie, Pharmazie
Freie Universität Berlin

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Ehemaliges studentisches Mitglied des Leitungsgremium des Graduiertenkollegs

Dissertationsthema:

Stimuli-responsive core multishell (CMS) nanocarriers for drug delivery

Erstbetreuer:                           Prof. Dr. Rainer Haag

Zweitbetreuerin:                       PD Dr. Martina Meinke

Drittbetreuer/Mentor:                Jun.-Prof. Dr. Marcelo Calderón


Publikationen:

Jager J, Obst K, Lohan SB, Voktorov J, Staufenbiel S, Renz H, Unbehauen M, Haag R, Hedtrich S, Teutloff C, Meinke MC, Danker K, Dommisch H 2017. Characterization of hyperbranched core-multishell nanocarriers as an innovative drug delivery system for the application at the oral mucosa. J Periodontal Res. Epub ahead of print. DOI 10.1111/jre.12487

Unbehauen ML, Fleige E, Paulus F, Schemmer B, Mecking S, Moré SD, Haag R 2017. Biodegradable core–multishell nanocarriers: Influence of inner shell structure on the encapsulation behavior of dexamethasone and tacrolimus. Polymers 9, 316  DOI 10.3390/polym9080316 (17 pages)

Lohan SB, Saeidpour S, Solik A, Schanzer S, Richter H, Dong P, Darvin ME, Bodmeier R, Patzelt A, Zoubari G, Unbehauen M, Haag R, Lademann J, Teutloff C, Bittl R, Meinke MC 2017. Investigation of the cutaneous penetration behavior of dexamethasone loaded to nano-sized lipid particles by EPR spectroscopy, and confocal Raman and Laser scanning microscopy. Accepted for publication in  Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.12.018

Müller F, Hönzke S, Luthardt W-O, Wong EL, Unbehauen M, Bauer J, Haag R, Hedtrich S, Rühl E, Rademann J 2017. Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery. Accepted for publication in Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.12.013

Saeidpour S, Lohan SB, Solik A, Paul V, Bodmeier R, Zoubari G, Unbehauen M, Haag R, Bittl R, Meinke MC, Teutloff C 2017. Drug distribution in nanostructured lipid particles. Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.10.008 (Epub ahead of print)

Saeidpour S, Lohan SB, Anske M, Unbehauen M, Fleige E, Haag R, Meinke MC, Bittl R, Teutloff C 2017. Localization of dexamethasone within dendritic core-multishell (CMS) nanoparticles and skin penetration properties studied by multi-frequency electron paramagnetic resonance spectroscopy (EPR). Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.10.001 (Epub ahead of print)

Radbruch M, Pischon H, Ostrowski A, Volz P, Brodwolf R, Neumann F, Unbehauen M, Kleuser B, Haag R, Ma N, Alexiev U, Mundhenk L, Gruber AD 2017. Dendritic core-multishell nanocarriers in murine models of healthy and atopic skin. Nanoscale Res Lett 12:64 DOI 10.1186/s11671-017-1835-0 (online publication, 12 pages)

Hönzke S, Gerecke C, Elpelt A, Zhang N, Unbehauen M, Kral V, Fleige E, Paulus F, Haag R, Schäfer-Korting M, Kleuser B, Hedtrich S 2017. Tailored dendritic core-multishell nanocarriers for efficient dermal drug delivery: A systematic top-down approach from synthesis to preclinical testing. J Control Release 242:50-63. DOI 10.1016/j.jconrel.2016.06.030

Pischon H, Radbruch M, Ostrowski A, Volz P, Gerecke C, Unbehauen M, Hönzke S, Hedtrich S, Fluhr JW, Haag R, Kleuser B, Alexiev U, Gruber AD, Mundhenk L 2016. Stratum corneum targeting by dendritic core-multishell-nanocarriers in a mouse model of psoriasis. Nanomedicine: NBM 13:317-327 DOI 10.1016/j.nano.2016.09.004