Dr. med. Alexa Patzelt, Dermatologin

Postdoktorandin in der Arbeitsgruppe Prof. Dr. Dr.-Ing. J. Lademann (TP C05)
Bereich experimentelle und angewandte Physiologie der Haut / Center of Experimental & Applied Cutaneous Physiology
Klinik für Dermatologie, Venerologie und Allergologie
Charité Universitätsmedizin Berlin

Kontakt:
alexa.patzelt (at) charite.de

Arbeitsgebiet: Intercellular and Follicular Penetration

Teilprojekt C05:

Dermal Trigger parameters for drug release from Nanocarriers


SFB 1112-Publikationen:

Lohan SB, Saeidpour S, Solik A, Schanzer S, Richter H, Dong P, Darvin ME, Bodmeier R, Patzelt A, Zoubari G, Unbehauen M, Haag R, Lademann J, Teutloff C, Bittl R, Meinke MC 2017. Investigation of the cutaneous penetration behavior of dexamethasone loaded to nano-sized lipid particles by EPR spectroscopy, and confocal Raman and Laser scanning microscopy. Accepted for publication in  Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.12.018

Radtke M, Patzelt A, Knorr F, Lademann J, Netz RR 2016. Ratchet effect for nanoparticle transport in hair follicles. Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.10.005 (Epub ahead of print)

Tran NBNN, Knorr F, Mak WC, Cheung KY, Richter H, Meinke M, Lademann J, Patzelt A 2016. Gradient-dependent release of the model drug TRITC-dextran from FITC-labeled BSA hydrogel nanocarriers in the hair follicles of porcine ear skin. Eur J Pharm Biopharm, in press, DOI 10.1016/j.ejpb.2016.2016.09.016 (Epub ahead of print)

Patzelt A, Mak WC, Jung S, Knorr F, Meinke MC, Richter H, Rühl E, Cheung KY, Tran NBNN, Lademann J 2017. Do nanoparticles have a future in dermal drug delivery? J Control Release, 246: 174-182, DOI 10.1016/j.jconrel.2016.09.015

Knorr F, Patzelt A, Darvin ME, Lehr C-M, Schäfer U, Gruber AD, Ostrowski A, Lademann J 2016. Penetration of topically applied nanocarriers into the hair follicles of dog and rat dorsal skin and porcine ear skin. Vet Dermatol 27:256-e60 DOI 10.1111/vde.12325

Lademann J, Richter H, Knorr F, Patzelt A, Darvin ME, Rühl E, Cheung KY, Lai KK, Renneberg R, Mak WC 2016. Triggered release of model drug from FITC-AuNP-doped BSA nanocarriers in hair follicles using IRA radiation. Acta Biomater 30:388-396 DOI 10.1016/j.actbio.2015.11.052

Lademann J, Knorr F, Richter H, Jung S, Meinke MC, Rühl E, Alexiev U, Calderon M, Patzelt A 2015. Hair follicles as a target structure for nanoparticles. J Innov Opt Health Sci 8:530004 (8 pages) DOI 10.1142/S1793545815300049